LabInstruct: Benchmarking Situated Instructional Video Generation for Lab Procedures

Yuming Fu, Weijia Wu, Jing Chen, Jiahao Tang, Feifei Chen, Hongyu Zhu, Xin Jin, Alex Jinpeng Wang

Central South University · National University of Singapore · Beijing University of Posts and Telecommunications · Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences · Monash University

Published September 29, 2026 · on the feed October 15, 2026 · ▲ 16 · arXiv 2610.14020

The abstract

Self-driving laboratories (SDLs) aim to automate the full experimental loop, from scientific decision-making to physical execution. Ideally, AI-generated plans could be carried out directly by robotic systems, but reliable automation remains difficult in complex, open-world laboratory environments, where experiments often involve fine-grained manipulation, long-horizon procedures, and substantial variation across tasks and setups. Humans therefore remain an important execution interface between AI-generated plans and physical experiments, creating a need for clear and effective human-facing experimental guidance. Because laboratory procedures are inherently visual, spatial, and dynamic, video is particularly well suited to communicating apparatus configurations, manipulation actions, temporal dependencies, and state changes. Recent advances in video generation now make it possible to synthesize experimental demonstrations directly from an initial workspace image and a natural-language instruction. However, whether such models can reliably communicate real laboratory procedures has not been systematically studied. We introduce LabInstruct, a benchmark for situated instructional video generation in real laboratories. LabInstruct contains 204 tasks across 5 scientific disciplines, with real reference executions and structured annotations of objects, actions, contacts, and state transitions. Evaluating 8 frontier image-to-video models, we find that visually plausible generations frequently remain procedurally incorrect, revealing a substantial gap between visual realism and the reliability required for experimental instruction.

The Brief

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Transcript

LabInstruct. Benchmarking Situated Instructional Video Generation for Lab Procedures. By Yuming Fu and seven others, from Central South University, the National University of Singapore, and three other institutions. Published on the twenty-ninth of September. Its code repository is public and real: about twenty-five source files.

Self-driving laboratories aim to automate the whole experimental loop, from scientific decision-making through to physical execution. Ideally, plans written by AI would be carried out directly by robots. But reliable automation is still hard in complex, open-world labs. Experiments there involve fine-grained manipulation, long procedures, and a great deal of variation from one task and one setup to the next. So humans remain an important execution interface, standing between the plans an AI produces and the physical experiment. That creates a need for guidance aimed at people: clear, effective, and easy to follow.

Lab procedures are inherently visual, spatial and dynamic, which makes video a natural medium for that guidance. It can show how apparatus is configured, what manipulation is performed, what depends on what in time, and how states change. Recent video generation can now synthesize an experimental demonstration directly from an image of the starting workspace and an instruction in natural language. Whether such models can reliably communicate real lab procedures, though, has not been systematically studied.

LabInstruct is a benchmark for situated instructional video generation in real laboratories. Situated here means the video has to start from the actual workspace in the image. And the question is not only whether a generated video looks real, but whether it gets the procedure right.

The benchmark contains two hundred and four tasks, drawn from five scientific disciplines. Each task comes with a real reference execution, so there is a recording of the procedure done properly. Each also carries structured annotations of the objects, actions, contacts and state transitions involved, which give the evaluation something concrete to check against.

Eight frontier image-to-video models were evaluated. The main finding is that generations which look visually plausible frequently remain procedurally incorrect. The authors describe a substantial gap between visual realism and the reliability that experimental instruction requires.

Looking right and being right are different properties, and for someone following a video at the bench, only the second one counts. With real reference executions and annotated steps, this benchmark gives a way to tell the two apart.

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